ABSTRACT
Objectives: Diabetic Nephropathy (DN) is a leading cause of chronic kidney disease and end stage renal failure worldwide. This study aimed to evaluate the association between oxidants, antioxidants and microalbuminuria in Diabetic Nephropathy compared with Type II Diabetes Mellitus (DM). Methods: The study includes 60 Type II Diabetes Mellitus and 40 Diabetic Nephropathy Patients. Parameters performed HbA1c, urea, creatinine, total proteins, microalbuminuria, glutathione peroxidase and malondialdehyde(MDA). Results: The levels of HbA1c, urea, creatinine, microalbuminuria and malondialdehyde are significantly higher in DN compared with Type II DM. the levels of T.P and glutathione peroxidase are decreased in DN compared with Type II DM. Conclusion: Low levels of glutathione peroxidase and total proteins were observed in DN. HbA1c, urea, creatinine, microalbuminuria and malondialdehyde levels were elevated in DN compared with Type II DM.
ABSTRACT
Background: The present study was conducted to evaluate glycosylated hemoglobin and electrolyte status in Diabetic ketoacidosis subjects compared with controlled type II diabetes mellitus. Methods: Totally 100 subjects were included in this study(75 known DKA subjects and 25 controlled type II Diabetes Mellitus subjects). 5ml of venous blood samples are collected from subjects, Biochemical parameters performed Fasting blood sugar, Post prandial blood sugar by Glucose oxidase and peroxidase method, Glycosylated hemoglobin by Ion exchange High performance liquid chromatography, serum electrolytes levels are estimated by Ion selective electrode method. Results: The serum levels of FBS, PPBS, HbA1c levels are high in DKA compared with controlled Type II DM. the serum levels of sodium are significantly decreased in DKA compared with controlled Type II DM. The serum levels of potassium and chloride are high in DKA compared with controlled Type II DM. Conclusion: We concluded that electrolyte imbalance is high in DKA due to hyperglycemic hyper-osmolality and insulin deficiency frequently leads to electrolyte imbalance. HbA1c, FBS, PPBS levels are elevated in DKA due to uncontrolled hyperglycemia.